This interference decreases the efficiency by which amitriptyline is metabolized in the liver, leading to abnormally high spikes in amitriptyline plasma concentrations.
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incubations with human liver microsomes showed no evidence of clinically significant metabolic interactions between tamsulosin hydrochloride and amitriptyline, albuterol beta agonist , glyburide glibenclamide and finasteride 5alpha-reductase inhibitor for treatment of bph .
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amitriptyline produced dose-dependent analgesia to each of 3 different noxious stimuli in 2 studies.
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amitriptyline is metabolized by n-demethylation and bridge hydroxylation in man, rabbit, and rat.
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