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1 multi-drug resistant tuberculosis mdr-tb , defined as mycobacterium tuberculosis mtb resistant to both isoniazid and rifampicin, is a worldwide problem with an estimated 14 million cases in 2009.

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pimavanserin major because pimavanserin is primarily metabolized by cyp3a4 and cyp3a5, the manufacturer recommends that the pimavanserin dose be reduced to 17 mg day po in patients receiving strong inhibitors of cyp3a4 such as isoniazid, inh.


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