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antiarrhythmics and proarrhythmic events have been observed by patients taking digoxin along with this drug.

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previous esophageal gastric surgery pregnant or nursing females clinically significant abnormal laboratory values medical condition that may be adversely impacted by participation in this study history of or current drug or alcohol abuse known malignancy need for concurrent therapy with any acid suppressive therapy other than the study drug, antacids, alginates, nsaids, 165 mg asa, prostaglandin analogs, prokinetic drug, antineoplastic agents, ketoconazole, itraconazole, voriconazole, clarithromycin, telithromycin, hiv protease inhibitors, rifampin, phenobarbital, or digoxin use of investigational drug or experimental device within 30 days prior to screening.

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these results mean that among af patients taking digoxin compared to those not on digoxin in the affirm trial, within five years one additional patient out of six will die from any cause, one additional patient out of eight will die from cardiovascular causes, and one additional patient out of 16 will die from arrhythmias, samy claude elayi, associate professor of medicine at the gill heart institute, university of kentucky, in lexington, ky.


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