However, based on in vitro data, blood concentrations of dutas may increase in the presence of inhibitors of cyp3a4 5 such as ritonavir, ketoconazole, verapamil, diltiazem, cimetidine, troleandomycin, and ciprofloxacin.

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ciprofloxacin is a cyp3a4 inhibitor, while darunavir is a cyp3a4 substrate.

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ciprofloxacin may cause swelling or tearing of a tendon the fiber that connects bones to muscles in the body , especially in the achilles tendon of the heel.

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