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in the 6-month migraine prophylaxis controlled trials, which used a slower titration regimen 25 mg day weekly increments , the proportion of patients who experienced one or more cognitive-related adverse reactions was 19 for topamax 50 mg day, 22 for 100 mg day the recommended dose , 28 for 200 mg day, and 10 for placebo.

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subsidiary of johnson drug administration fda first approved topamax for treatment of epilepsy in 1996.

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